Drug interactions
Peginterferon alfa 2a + Tizanidine
Severity: Moderate
Peginterferon alfa 2a and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2a can inhibit CYP1A2 and raise exposure to CYP1A2 substrates, which may increase tizanidine's hypotensive and sedative effects. The effect is moderate and less than with potent inhibitors.
What this interaction means in plain words
Peginterferon alfa 2a and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Peginterferon alfa 2a belongs to Anti Virals; Tizanidine belongs to Musculoskeletal.
Why it happens
Reduced CYP1A2 activity from interferon-mediated suppression of hepatic enzymes.
What to do
Monitor blood pressure, heart rate and sedation, and reduce the tizanidine dose if adverse effects occur. Reassess dosing when interferon therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Peginterferon alfa 2a
Frequently asked questions
Can I take Peginterferon alfa 2a with Tizanidine?
MediHelp rates the interaction as moderate. Peginterferon alfa 2a and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peginterferon alfa-2a can inhibit CYP1A2 and raise exposure to CYP1A2 substrates, which may increase tizanidine's hypotensive and sedative effects. The effect is moderate and less than with potent inhibitors.
How serious is the interaction between Peginterferon alfa 2a and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, and reduce the tizanidine dose if adverse effects occur. Reassess dosing when interferon therapy ends.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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