Drug interactions
Penbutolol + Tizanidine
Severity: Moderate
Penbutolol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine lowers blood pressure and heart rate through central alpha-2 stimulation, and penbutolol is a beta-blocker that also reduces heart rate and blood pressure. Combined use may lead to additive hypotension and bradycardia.
What this interaction means in plain words
Penbutolol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic reduction of sympathetic tone, blood pressure and heart rate.
What to do
Monitor blood pressure and heart rate, especially during initiation and dose changes. Reduce the dose of one drug if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Penbutolol with Tizanidine?
MediHelp rates the interaction as moderate. Penbutolol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine lowers blood pressure and heart rate through central alpha-2 stimulation, and penbutolol is a beta-blocker that also reduces heart rate and blood pressure. Combined use may lead to additive hypotension and bradycardia.
How serious is the interaction between Penbutolol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially during initiation and dose changes. Reduce the dose of one drug if symptomatic hypotension or bradycardia develops.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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