Drug interactions
Pentazocine + Scullcap
Severity: Moderate
Pentazocine and Scullcap: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap herbal products are traditionally used as mild sedatives and may add to opioid drowsiness. Evidence is limited and product content is variable.
What this interaction means in plain words
Pentazocine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive central nervous system depression, likely via GABAergic activity of the herb.
What to do
Advise avoiding sedative herbal products while taking pentazocine. Monitor for excess drowsiness if they are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Pentazocine with Scullcap?
MediHelp rates the interaction as moderate. Pentazocine and Scullcap can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Skullcap herbal products are traditionally used as mild sedatives and may add to opioid drowsiness. Evidence is limited and product content is variable.
How serious is the interaction between Pentazocine and Scullcap?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding sedative herbal products while taking pentazocine. Monitor for excess drowsiness if they are used.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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