Drug interactions
Pentazocine + Sufentanil sl
Severity: Major
Pentazocine and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining pentazocine with sublingual sufentanil may reduce analgesia and trigger withdrawal in opioid-dependent patients. It may also cause hypotension, profound sedation and respiratory depression.
What this interaction means in plain words
Pentazocine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mixed agonist-antagonist activity opposing a full mu agonist along with additive CNS and respiratory depression.
What to do
Avoid concurrent use; keep to one opioid. If unavoidable, use minimum doses and monitor respiration, sedation and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Pentazocine with Sufentanil sl?
MediHelp rates the interaction as major. Pentazocine and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining pentazocine with sublingual sufentanil may reduce analgesia and trigger withdrawal in opioid-dependent patients. It may also cause hypotension, profound sedation and respiratory depression.
How serious is the interaction between Pentazocine and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; keep to one opioid. If unavoidable, use minimum doses and monitor respiration, sedation and blood pressure.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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