Drug interactions
Pentobarbital + Piroxicam
Severity: Minor
Pentobarbital and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic enzymes and may increase piroxicam metabolism, possibly reducing its analgesic or anti-inflammatory effect. The magnitude is uncertain and effects develop over days.
What this interaction means in plain words
Pentobarbital and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP2C9 increases piroxicam clearance.
What to do
Assess response to piroxicam and increase the dose cautiously if efficacy is lost; reassess when the barbiturate is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Pentobarbital with Piroxicam?
MediHelp rates the interaction as minor. Pentobarbital and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentobarbital induces hepatic enzymes and may increase piroxicam metabolism, possibly reducing its analgesic or anti-inflammatory effect. The magnitude is uncertain and effects develop over days.
How serious is the interaction between Pentobarbital and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess response to piroxicam and increase the dose cautiously if efficacy is lost; reassess when the barbiturate is stopped.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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