Drug interactions
Perindopril + Sirolimus
Severity: Major
Perindopril and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus raises the risk of angioedema in patients taking ACE inhibitors. Swelling of the face, lips, tongue or airway may occur and can be life-threatening.
What this interaction means in plain words
Perindopril and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perindopril belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR inhibition appears to add to ACE inhibitor-related bradykinin accumulation.
What to do
Prefer a different antihypertensive class where possible. If combined, counsel patients to seek urgent care for swelling and stop perindopril if angioedema occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Perindopril with Sirolimus?
MediHelp rates the interaction as major. Perindopril and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sirolimus raises the risk of angioedema in patients taking ACE inhibitors. Swelling of the face, lips, tongue or airway may occur and can be life-threatening.
How serious is the interaction between Perindopril and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different antihypertensive class where possible. If combined, counsel patients to seek urgent care for swelling and stop perindopril if angioedema occurs.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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