Drug interactions
Perphenazine + Phenylephrine
Severity: Minor
Perphenazine and Phenylephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has alpha-1 blocking properties that may reduce the pressor response to phenylephrine. Both agents may also affect cardiac rhythm in predisposed patients.
What this interaction means in plain words
Perphenazine and Phenylephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perphenazine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenergic receptors by the phenothiazine.
What to do
Monitor blood pressure and titrate phenylephrine to response. Check ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Phenylephrine?
MediHelp rates the interaction as minor. Perphenazine and Phenylephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine has alpha-1 blocking properties that may reduce the pressor response to phenylephrine. Both agents may also affect cardiac rhythm in predisposed patients.
How serious is the interaction between Perphenazine and Phenylephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate phenylephrine to response. Check ECG in patients with cardiac risk factors.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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