Drug interactions
Perphenazine + Propranolol
Severity: Moderate
Perphenazine and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine inhibits CYP2D6 and may increase propranolol concentrations, and each drug can lower blood pressure. Propranolol may in turn raise phenothiazine levels. This can cause hypotension, bradycardia and sedation.
What this interaction means in plain words
Perphenazine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
Perphenazine inhibits CYP2D6-mediated propranolol metabolism, with additive hypotensive effects.
What to do
Monitor blood pressure and heart rate when combining, and lower the propranolol dose if bradycardia or hypotension appears. Watch for increased sedation or extrapyramidal effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Propranolol?
MediHelp rates the interaction as moderate. Perphenazine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine inhibits CYP2D6 and may increase propranolol concentrations, and each drug can lower blood pressure. Propranolol may in turn raise phenothiazine levels. This can cause hypotension, bradycardia and sedation.
How serious is the interaction between Perphenazine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when combining, and lower the propranolol dose if bradycardia or hypotension appears. Watch for increased sedation or extrapyramidal effects.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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