Drug interactions
Perphenazine + Quinapril
Severity: Minor
Perphenazine and Quinapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can cause orthostatic hypotension through alpha-adrenergic blockade, and quinapril lowers blood pressure. Taken together, they may produce additive hypotension, particularly at the start of therapy or after dose increases, with a risk of dizziness and falls in older patients.
What this interaction means in plain words
Perphenazine and Quinapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic blood pressure lowering from alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, and counsel patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Quinapril?
MediHelp rates the interaction as minor. Perphenazine and Quinapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine can cause orthostatic hypotension through alpha-adrenergic blockade, and quinapril lowers blood pressure. Taken together, they may produce additive hypotension, particularly at the start of therapy or after dose increases, with a risk of dizziness and falls in older patients.
How serious is the interaction between Perphenazine and Quinapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug, and counsel patients to rise slowly.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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