Drug interactions
Perphenazine + Remimazolam
Severity: Major
Perphenazine and Remimazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam combined with other CNS depressants can cause profound sedation, respiratory depression and hypotension. Perphenazine adds to the sedative effect.
What this interaction means in plain words
Perphenazine and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perphenazine belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Titrate remimazolam carefully and monitor vital signs and oxygen saturation continuously. Ensure airway and resuscitation equipment is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Remimazolam
Frequently asked questions
Can I take Perphenazine with Remimazolam?
MediHelp rates the interaction as major. Perphenazine and Remimazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Remimazolam combined with other CNS depressants can cause profound sedation, respiratory depression and hypotension. Perphenazine adds to the sedative effect.
How serious is the interaction between Perphenazine and Remimazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully and monitor vital signs and oxygen saturation continuously. Ensure airway and resuscitation equipment is available.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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