Drug interactions
Perphenazine + Sage
Severity: Minor
Perphenazine and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is sedating, and some sage preparations are traditionally described as having sedative or CNS effects. Concurrent use could theoretically add to drowsiness and impaired alertness, though clinical data are scarce.
What this interaction means in plain words
Perphenazine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive CNS depression; not firmly established.
What to do
Advise patients to be aware of increased drowsiness and to avoid driving if impaired, and to report herbal use to their prescriber.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Sage?
MediHelp rates the interaction as minor. Perphenazine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine is sedating, and some sage preparations are traditionally described as having sedative or CNS effects. Concurrent use could theoretically add to drowsiness and impaired alertness, though clinical data are scarce.
How serious is the interaction between Perphenazine and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to be aware of increased drowsiness and to avoid driving if impaired, and to report herbal use to their prescriber.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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