Drug interactions
Perphenazine + Sumatriptan intranasal
Severity: Moderate
Perphenazine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics and triptans both act on serotonergic and dopaminergic systems, and serotonin syndrome or neuroleptic malignant syndrome has been theorized. Documented cases are rare and the risk is considered low.
What this interaction means in plain words
Perphenazine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic and dopaminergic effects; the mechanism is not firmly established.
What to do
Monitor for hyperthermia, rigidity, agitation, tremor and autonomic instability, and stop both drugs if features of serotonin syndrome or NMS appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Perphenazine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics and triptans both act on serotonergic and dopaminergic systems, and serotonin syndrome or neuroleptic malignant syndrome has been theorized. Documented cases are rare and the risk is considered low.
How serious is the interaction between Perphenazine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, agitation, tremor and autonomic instability, and stop both drugs if features of serotonin syndrome or NMS appear.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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