Drug interactions
Perphenazine + Topiramate
Severity: Moderate
Perphenazine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so combined use may increase drowsiness, dizziness and impaired concentration.
What this interaction means in plain words
Perphenazine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Titrate topiramate slowly and monitor for excessive sedation and cognitive impairment. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Topiramate
Frequently asked questions
Can I take Perphenazine with Topiramate?
MediHelp rates the interaction as moderate. Perphenazine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so combined use may increase drowsiness, dizziness and impaired concentration.
How serious is the interaction between Perphenazine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate topiramate slowly and monitor for excessive sedation and cognitive impairment. Advise patients to avoid driving until the response is known.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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