Drug interactions
Perphenazine + Triazolam
Severity: Moderate
Perphenazine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine and triazolam are both sedating, so together they increase drowsiness, impaired psychomotor performance and the risk of falls. Respiratory depression is more likely in older or debilitated patients.
What this interaction means in plain words
Perphenazine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through antipsychotic receptor blockade and benzodiazepine GABA-A potentiation.
What to do
Use the lowest effective doses, advise against alcohol and driving, and monitor older patients for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Triazolam?
MediHelp rates the interaction as moderate. Perphenazine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine and triazolam are both sedating, so together they increase drowsiness, impaired psychomotor performance and the risk of falls. Respiratory depression is more likely in older or debilitated patients.
How serious is the interaction between Perphenazine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, advise against alcohol and driving, and monitor older patients for oversedation.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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