Drug interactions
Perphenazine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Perphenazine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, may prolong the QT interval and cause tachycardia, and perphenazine adds QT prolongation. Systemic exposure from inhalation is low, so the clinical effect is generally modest, but caution is needed in patients with heart disease.
What this interaction means in plain words
Perphenazine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and cardiovascular effects of beta-agonist stimulation.
What to do
Monitor ECG and heart rate in patients with cardiac risk factors and correct hypokalemia. Consider an alternative bronchodilator if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Perphenazine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, may prolong the QT interval and cause tachycardia, and perphenazine adds QT prolongation. Systemic exposure from inhalation is low, so the clinical effect is generally modest, but caution is needed in patients with heart disease.
How serious is the interaction between Perphenazine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate in patients with cardiac risk factors and correct hypokalemia. Consider an alternative bronchodilator if QT risk is high.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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