Drug interactions
Perphenazine + Yohimbine
Severity: Moderate
Perphenazine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises blood pressure and heart rate and may cause anxiety, while perphenazine blocks alpha-1 receptors and can lower blood pressure. Effects may partly oppose each other and the net effect is unpredictable.
What this interaction means in plain words
Perphenazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing adrenergic effects of alpha-2 antagonism and phenothiazine alpha-1 blockade.
What to do
Monitor blood pressure, heart rate and anxiety or agitation, and avoid yohimbine in patients with psychosis or cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Yohimbine?
MediHelp rates the interaction as moderate. Perphenazine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises blood pressure and heart rate and may cause anxiety, while perphenazine blocks alpha-1 receptors and can lower blood pressure. Effects may partly oppose each other and the net effect is unpredictable.
How serious is the interaction between Perphenazine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and anxiety or agitation, and avoid yohimbine in patients with psychosis or cardiovascular disease.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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