Drug interactions
Perphenazine + Zolpidem
Severity: Moderate
Perphenazine and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine and zolpidem together can cause additive drowsiness and slowed reaction times. This raises the risk of falls and accidents, especially in older patients.
What this interaction means in plain words
Perphenazine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A enhancement and dopamine/histamine receptor blockade.
What to do
Use the lowest zolpidem dose and warn patients about driving and hazardous activities. Monitor for excessive sedation and reduce doses if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Zolpidem?
MediHelp rates the interaction as moderate. Perphenazine and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine and zolpidem together can cause additive drowsiness and slowed reaction times. This raises the risk of falls and accidents, especially in older patients.
How serious is the interaction between Perphenazine and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest zolpidem dose and warn patients about driving and hazardous activities. Monitor for excessive sedation and reduce doses if it occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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