Drug interactions
Pexidartinib + Praziquantel
Severity: Moderate
Pexidartinib and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a moderate CYP3A4 inducer and may reduce praziquantel exposure. Antiparasitic efficacy could be reduced.
What this interaction means in plain words
Pexidartinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pexidartinib belongs to Oncology; Praziquantel belongs to Anti Parasitic.
Why it happens
Pexidartinib induces CYP3A4, accelerating praziquantel metabolism.
What to do
Monitor for reduced response and consider post-treatment parasitological follow-up. Consider an alternative strategy if cure is critical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pexidartinib and Praziquantel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Praziquantel?
MediHelp rates the interaction as moderate. Pexidartinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is a moderate CYP3A4 inducer and may reduce praziquantel exposure. Antiparasitic efficacy could be reduced.
How serious is the interaction between Pexidartinib and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and consider post-treatment parasitological follow-up. Consider an alternative strategy if cure is critical.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
