Drug interactions
Pexidartinib + Quinine
Severity: Major
Pexidartinib and Quinine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a CYP3A4 inducer and can reduce quinine exposure. This may cause subtherapeutic levels and failure of malaria treatment.
What this interaction means in plain words
Pexidartinib and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Pexidartinib induces CYP3A4, accelerating the metabolism of quinine.
What to do
Avoid the combination and use an alternative antimalarial if possible. If unavoidable, monitor closely for lack of response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Quinine?
MediHelp rates the interaction as major. Pexidartinib and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib is a CYP3A4 inducer and can reduce quinine exposure. This may cause subtherapeutic levels and failure of malaria treatment.
How serious is the interaction between Pexidartinib and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antimalarial if possible. If unavoidable, monitor closely for lack of response.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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