Drug interactions
Pexidartinib + Siponimod
Severity: Moderate
Pexidartinib and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a CSF1R inhibitor with little immunosuppression, but it is hepatotoxic and is a CYP3A4 inducer, and siponimod is cleared by CYP2C9 and CYP3A4. Exposure to siponimod may fall and liver injury risk may overlap.
What this interaction means in plain words
Pexidartinib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pexidartinib belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Pexidartinib may induce CYP3A4, lowering siponimod exposure, and both drugs can affect liver function.
What to do
Monitor liver tests and clinical response to siponimod. Consider alternatives if hepatic abnormalities arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Siponimod?
MediHelp rates the interaction as moderate. Pexidartinib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is a CSF1R inhibitor with little immunosuppression, but it is hepatotoxic and is a CYP3A4 inducer, and siponimod is cleared by CYP2C9 and CYP3A4. Exposure to siponimod may fall and liver injury risk may overlap.
How serious is the interaction between Pexidartinib and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests and clinical response to siponimod. Consider alternatives if hepatic abnormalities arise.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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