Drug interactions
Pexidartinib + Vitamin a
Severity: Moderate
Pexidartinib and Vitamin a: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a serious hepatotoxicity risk, and high-dose vitamin A can also injure the liver. Concurrent use could add to liver injury, mainly with supplemental doses well above dietary intake.
What this interaction means in plain words
Pexidartinib and Vitamin a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pexidartinib belongs to Oncology; Vitamin a belongs to Gastrointestinal Tract.
Why it happens
Additive hepatotoxicity.
What to do
Avoid high-dose vitamin A supplements during pexidartinib therapy. Monitor liver tests per pexidartinib labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin a
- Acitretin + Vitamin a Major
- Etretinate + Vitamin a Major
- Isotretinoin + Vitamin a Major
- Palovarotene + Vitamin a Major
- Bexarotene + Vitamin a Moderate
- Minocycline + Vitamin a Moderate
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Vitamin a?
MediHelp rates the interaction as moderate. Pexidartinib and Vitamin a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a serious hepatotoxicity risk, and high-dose vitamin A can also injure the liver. Concurrent use could add to liver injury, mainly with supplemental doses well above dietary intake.
How serious is the interaction between Pexidartinib and Vitamin a?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose vitamin A supplements during pexidartinib therapy. Monitor liver tests per pexidartinib labeling.
What other medicines interact with Vitamin a?
MediHelp also lists interactions of Vitamin a with, for example, Acitretin, Etretinate, Isotretinoin. The full list is on the Vitamin a page.
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