Drug interactions
Phenelzine + Procarbazine
Severity: Contraindicated
Phenelzine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a weak MAO inhibitor, so adding it to phenelzine increases the risk of hypertensive crisis and serotonin syndrome and potentiates other interactions. Use of both is contraindicated.
What this interaction means in plain words
Phenelzine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive MAO inhibition leading to excess monoamine accumulation.
What to do
Avoid the combination and keep a 2-week gap between the drugs. Select an antidepressant without MAO inhibition for patients receiving procarbazine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Phenelzine with Procarbazine?
MediHelp rates the interaction as contraindicated. Phenelzine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine is a weak MAO inhibitor, so adding it to phenelzine increases the risk of hypertensive crisis and serotonin syndrome and potentiates other interactions. Use of both is contraindicated.
How serious is the interaction between Phenelzine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and keep a 2-week gap between the drugs. Select an antidepressant without MAO inhibition for patients receiving procarbazine.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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