Drug interactions
Phenelzine + Quetiapine
Severity: Moderate
Phenelzine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine with phenelzine may cause additive orthostatic hypotension and sedation. Serotonin toxicity or neuroleptic malignant syndrome are rare but possible when monoamine levels are raised in the presence of dopamine blockade.
What this interaction means in plain words
Phenelzine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects of MAO inhibition with D2/5-HT2A antagonism, alpha-1 blockade and histamine H1 antagonism.
What to do
Start quetiapine at a low dose and titrate slowly, monitoring blood pressure and sedation. Stop and treat urgently if hyperthermia, rigidity or autonomic instability occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Phenelzine with Quetiapine?
MediHelp rates the interaction as moderate. Phenelzine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine with phenelzine may cause additive orthostatic hypotension and sedation. Serotonin toxicity or neuroleptic malignant syndrome are rare but possible when monoamine levels are raised in the presence of dopamine blockade.
How serious is the interaction between Phenelzine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start quetiapine at a low dose and titrate slowly, monitoring blood pressure and sedation. Stop and treat urgently if hyperthermia, rigidity or autonomic instability occurs.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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