Drug interactions
Phenelzine + Saxagliptin-metformin
Severity: Moderate
Phenelzine and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-selective MAO inhibitors such as phenelzine can lower blood glucose and enhance the effect of antidiabetic drugs. When combined with saxagliptin-metformin, hypoglycemia is possible, particularly in patients with poor oral intake.
What this interaction means in plain words
Phenelzine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Additive glucose-lowering effect through pharmacodynamic synergism; MAO inhibitors may enhance insulin sensitivity and secretion.
What to do
Monitor blood glucose when phenelzine is started, changed or stopped. Reduce the antidiabetic dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Phenelzine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-selective MAO inhibitors such as phenelzine can lower blood glucose and enhance the effect of antidiabetic drugs. When combined with saxagliptin-metformin, hypoglycemia is possible, particularly in patients with poor oral intake.
How serious is the interaction between Phenelzine and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when phenelzine is started, changed or stopped. Reduce the antidiabetic dose if hypoglycemia occurs.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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