Drug interactions
phenelzine + sumatriptan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hypertensive crisis/serotonin toxicity; contraindicated.
Mechanism of action
MAO-A inhibition lowers triptan clearance.
Clinical management
Contraindicated.
Drug reference
References
Frequently asked questions
Can I take phenelzine with sumatriptan?
The interaction is rated: Contraindicated. Hypertensive crisis/serotonin toxicity; contraindicated.
How serious is the interaction between phenelzine and sumatriptan?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between phenelzine and sumatriptan managed?
Contraindicated.
Why do phenelzine and sumatriptan interact?
MAO-A inhibition lowers triptan clearance.
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