Drug interactions
Phenelzine + Ziprasidone
Severity: Moderate
Phenelzine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone with phenelzine may cause additive hypotension and sedation, and rarely serotonin toxicity or neuroleptic malignant syndrome. Ziprasidone also prolongs the QT interval, adding cardiac risk in susceptible patients.
What this interaction means in plain words
Phenelzine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenelzine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects of MAO inhibition with D2/5-HT2A antagonism, serotonin and norepinephrine reuptake inhibition and QT prolongation by ziprasidone.
What to do
Obtain a baseline ECG and electrolytes, and monitor QTc, blood pressure and mental status. Stop one agent if signs of serotonin toxicity or neuroleptic malignant syndrome develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Phenelzine with Ziprasidone?
MediHelp rates the interaction as moderate. Phenelzine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone with phenelzine may cause additive hypotension and sedation, and rarely serotonin toxicity or neuroleptic malignant syndrome. Ziprasidone also prolongs the QT interval, adding cardiac risk in susceptible patients.
How serious is the interaction between Phenelzine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes, and monitor QTc, blood pressure and mental status. Stop one agent if signs of serotonin toxicity or neuroleptic malignant syndrome develop.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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