Drug interactions
Phenobarbital + Piroxicam
Severity: Minor
Phenobarbital and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is an enzyme inducer and may lower piroxicam levels by accelerating its metabolism. Reduced symptom control could result, and levels may rise again after phenobarbital is stopped.
What this interaction means in plain words
Phenobarbital and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenobarbital induction of CYP2C9 increases piroxicam clearance.
What to do
Monitor therapeutic response to piroxicam and adjust the dose if needed; reassess when phenobarbital is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Phenobarbital with Piroxicam?
MediHelp rates the interaction as minor. Phenobarbital and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital is an enzyme inducer and may lower piroxicam levels by accelerating its metabolism. Reduced symptom control could result, and levels may rise again after phenobarbital is stopped.
How serious is the interaction between Phenobarbital and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor therapeutic response to piroxicam and adjust the dose if needed; reassess when phenobarbital is started or stopped.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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