Drug interactions
Phenobarbital + Rimegepant
Severity: Moderate
Phenobarbital and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and can lower rimegepant concentrations, potentially causing loss of migraine efficacy.
What this interaction means in plain words
Phenobarbital and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 metabolism of rimegepant.
What to do
Avoid concomitant use; if migraine control worsens, switch to an alternative not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Phenobarbital with Rimegepant?
MediHelp rates the interaction as moderate. Phenobarbital and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital induces CYP3A4 and can lower rimegepant concentrations, potentially causing loss of migraine efficacy.
How serious is the interaction between Phenobarbital and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; if migraine control worsens, switch to an alternative not dependent on CYP3A4.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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