Drug interactions
Phenoxybenzamine + Piroxicam
Severity: Minor
Phenoxybenzamine and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may partly reduce the blood pressure lowering effect of phenoxybenzamine. Evidence is limited and the effect is probably small.
What this interaction means in plain words
Phenoxybenzamine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID inhibition of vasodilatory prostaglandins with sodium and fluid retention may oppose alpha-blockade.
What to do
Monitor blood pressure and adjust the phenoxybenzamine dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Phenoxybenzamine with Piroxicam?
MediHelp rates the interaction as minor. Phenoxybenzamine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may partly reduce the blood pressure lowering effect of phenoxybenzamine. Evidence is limited and the effect is probably small.
How serious is the interaction between Phenoxybenzamine and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the phenoxybenzamine dose if control worsens.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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