Drug interactions
Phentolamine + Ramipril
Severity: Moderate
Phentolamine and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is a nonselective alpha-blocker with strong vasodilating effects. Combined with ramipril, it can produce an exaggerated drop in blood pressure, especially with first doses or in volume-depleted patients.
What this interaction means in plain words
Phentolamine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phentolamine belongs to Cardiovascular; Ramipril belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-adrenergic blockade and inhibition of angiotensin II formation.
What to do
Monitor blood pressure closely when phentolamine is given to patients on ramipril, and be ready to treat hypotension with fluids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Phentolamine with Ramipril?
MediHelp rates the interaction as moderate. Phentolamine and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is a nonselective alpha-blocker with strong vasodilating effects. Combined with ramipril, it can produce an exaggerated drop in blood pressure, especially with first doses or in volume-depleted patients.
How serious is the interaction between Phentolamine and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely when phentolamine is given to patients on ramipril, and be ready to treat hypotension with fluids.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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