Drug interactions
Phentolamine + Trandolapril
Severity: Moderate
Phentolamine and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentolamine is an alpha-adrenergic blocker that causes vasodilation. With an ACE inhibitor, additive hypotension may occur, notably after the first doses.
What this interaction means in plain words
Phentolamine and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phentolamine belongs to Cardiovascular; Trandolapril belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure reduction from alpha blockade and ACE inhibition.
What to do
Monitor blood pressure closely, including standing readings, when starting or increasing either drug. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Phentolamine with Trandolapril?
MediHelp rates the interaction as moderate. Phentolamine and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentolamine is an alpha-adrenergic blocker that causes vasodilation. With an ACE inhibitor, additive hypotension may occur, notably after the first doses.
How serious is the interaction between Phentolamine and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely, including standing readings, when starting or increasing either drug. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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