Drug interactions
Phenytoin + Talquetamab
Severity: Moderate
Phenytoin and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab-induced cytokine release can transiently suppress CYP enzymes, potentially raising phenytoin levels and toxicity. Risk is highest during step-up dosing and around cytokine release syndrome.
What this interaction means in plain words
Phenytoin and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenytoin belongs to Central Nervous System; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP450 enzymes reduces phenytoin clearance.
What to do
Monitor phenytoin concentrations and toxicity signs, especially after initiation and during cytokine release syndrome. Adjust the phenytoin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Phenytoin with Talquetamab?
MediHelp rates the interaction as moderate. Phenytoin and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab-induced cytokine release can transiently suppress CYP enzymes, potentially raising phenytoin levels and toxicity. Risk is highest during step-up dosing and around cytokine release syndrome.
How serious is the interaction between Phenytoin and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin concentrations and toxicity signs, especially after initiation and during cytokine release syndrome. Adjust the phenytoin dose as needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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