Drug interactions
Pilocarpine + Scopolamine
Severity: Moderate
Pilocarpine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist and scopolamine is a muscarinic antagonist, so each can reduce the effect of the other. Scopolamine may reduce the effect of pilocarpine on salivation or intraocular pressure.
What this interaction means in plain words
Pilocarpine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pilocarpine belongs to Miscellaneous; Scopolamine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Avoid concurrent use when possible. If needed, monitor for loss of pilocarpine efficacy and adjust the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Pilocarpine with Scopolamine?
MediHelp rates the interaction as moderate. Pilocarpine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist and scopolamine is a muscarinic antagonist, so each can reduce the effect of the other. Scopolamine may reduce the effect of pilocarpine on salivation or intraocular pressure.
How serious is the interaction between Pilocarpine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible. If needed, monitor for loss of pilocarpine efficacy and adjust the dose.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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