Drug interactions
Pimavanserin + Procarbazine
Severity: Moderate
Pimavanserin and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting properties, and pimavanserin has serotonergic activity (5-HT2A inverse agonism) with antipsychotic properties. Together they may raise the risk of serotonin toxicity or neuroleptic malignant syndrome, although direct evidence is limited.
What this interaction means in plain words
Pimavanserin and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimavanserin belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Possible pharmacodynamic interaction between MAO inhibition and serotonergic and antipsychotic activity; the mechanism is not well established.
What to do
Monitor for mental status change, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity. Stop one or both drugs if features of serotonin syndrome or neuroleptic malignant syndrome emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Pimavanserin with Procarbazine?
MediHelp rates the interaction as moderate. Pimavanserin and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has monoamine oxidase inhibiting properties, and pimavanserin has serotonergic activity (5-HT2A inverse agonism) with antipsychotic properties. Together they may raise the risk of serotonin toxicity or neuroleptic malignant syndrome, although direct evidence is limited.
How serious is the interaction between Pimavanserin and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity. Stop one or both drugs if features of serotonin syndrome or neuroleptic malignant syndrome emerge.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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