Drug interactions
Pimavanserin + Quizartinib
Severity: Major
Pimavanserin and Quizartinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and quizartinib carries a boxed warning for QT prolongation and torsades de pointes. Combining them increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Pimavanserin and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimavanserin belongs to Central Nervous System; Quizartinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Avoid if possible; if unavoidable, monitor ECGs frequently and keep potassium and magnesium normal. Reduce or hold quizartinib if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Pimavanserin with Quizartinib?
MediHelp rates the interaction as major. Pimavanserin and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and quizartinib carries a boxed warning for QT prolongation and torsades de pointes. Combining them increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Pimavanserin and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, monitor ECGs frequently and keep potassium and magnesium normal. Reduce or hold quizartinib if QTc rises significantly.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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