Drug interactions
Pimavanserin + Sertraline
Severity: Moderate
Pimavanserin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin prolongs the QT interval and its labeling advises avoiding use with other drugs that prolong QT. Sertraline has a small QT effect, so the combination adds modestly to arrhythmia risk, which is greater with other risk factors.
What this interaction means in plain words
Pimavanserin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimavanserin belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check ECG and electrolytes at baseline and monitor during therapy, especially in patients with cardiac disease. Consider alternatives if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Pimavanserin with Sertraline?
MediHelp rates the interaction as moderate. Pimavanserin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin prolongs the QT interval and its labeling advises avoiding use with other drugs that prolong QT. Sertraline has a small QT effect, so the combination adds modestly to arrhythmia risk, which is greater with other risk factors.
How serious is the interaction between Pimavanserin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and monitor during therapy, especially in patients with cardiac disease. Consider alternatives if QTc becomes prolonged.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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