Drug interactions
Pimozide + Rilpivirine
Severity: Major
Pimozide and Rilpivirine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide prolongs the QT interval and rilpivirine, at supratherapeutic doses, can also prolong QT. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Pimozide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pimozide belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT interval prolongation.
What to do
Avoid the combination where possible; if unavoidable, obtain a baseline and follow-up ECG and correct potassium and magnesium. Consider alternative antiretrovirals or antipsychotics.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Pimozide with Rilpivirine?
MediHelp rates the interaction as major. Pimozide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimozide prolongs the QT interval and rilpivirine, at supratherapeutic doses, can also prolong QT. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Pimozide and Rilpivirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, obtain a baseline and follow-up ECG and correct potassium and magnesium. Consider alternative antiretrovirals or antipsychotics.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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