Drug interactions
Pimozide + Tazemetostat
Severity: Moderate
Pimozide and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A inducer and may reduce pimozide exposure and effect. Pimozide is a CYP3A substrate with a narrow therapeutic margin, so changes in levels matter, and tazemetostat itself is a CYP3A substrate.
What this interaction means in plain words
Pimozide and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing pimozide metabolism.
What to do
Monitor tic control and adjust pimozide to response, with ECG checks after dose changes. Reassess pimozide dosing when tazemetostat is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Pimozide with Tazemetostat?
MediHelp rates the interaction as moderate. Pimozide and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak to moderate CYP3A inducer and may reduce pimozide exposure and effect. Pimozide is a CYP3A substrate with a narrow therapeutic margin, so changes in levels matter, and tazemetostat itself is a CYP3A substrate.
How serious is the interaction between Pimozide and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tic control and adjust pimozide to response, with ECG checks after dose changes. Reassess pimozide dosing when tazemetostat is stopped.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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