Drug interactions
Pimozide + Teduglutide
Severity: Moderate
Pimozide and Teduglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs. For pimozide, which has a narrow therapeutic index and QT liability, higher absorption could raise exposure.
What this interaction means in plain words
Pimozide and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Teduglutide belongs to Endocrine.
Why it happens
Enhanced intestinal absorptive capacity may increase oral pimozide uptake.
What to do
Monitor for pimozide adverse effects such as sedation, extrapyramidal symptoms and QT prolongation when teduglutide is started. Adjust the pimozide dose and check ECG as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Teduglutide
- Chlordiazepoxide + Teduglutide Moderate
- Clonazepam + Teduglutide Moderate
- Colchicine + Teduglutide Moderate
- Cyclosporin + Teduglutide Moderate
- Digoxin + Teduglutide Moderate
- Ethosuximide + Teduglutide Moderate
Frequently asked questions
Can I take Pimozide with Teduglutide?
MediHelp rates the interaction as moderate. Pimozide and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs. For pimozide, which has a narrow therapeutic index and QT liability, higher absorption could raise exposure.
How serious is the interaction between Pimozide and Teduglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pimozide adverse effects such as sedation, extrapyramidal symptoms and QT prolongation when teduglutide is started. Adjust the pimozide dose and check ECG as needed.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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