Drug interactions
Pimozide + Ziconotide
Severity: Moderate
Pimozide and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide can cause dizziness, confusion and sedation, and pimozide adds to these central nervous system effects. Combined use may increase cognitive impairment and psychiatric adverse effects.
What this interaction means in plain words
Pimozide and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and cognitive impairment.
What to do
Monitor for sedation, confusion and mood changes, and reduce the dose of one agent if impairment develops. Ziconotide should be stopped if serious neuropsychiatric effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Pimozide with Ziconotide?
MediHelp rates the interaction as moderate. Pimozide and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide can cause dizziness, confusion and sedation, and pimozide adds to these central nervous system effects. Combined use may increase cognitive impairment and psychiatric adverse effects.
How serious is the interaction between Pimozide and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and mood changes, and reduce the dose of one agent if impairment develops. Ziconotide should be stopped if serious neuropsychiatric effects occur.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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