Drug interactions
Pimozide + Zileuton
Severity: Contraindicated
Pimozide and Zileuton: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton may increase pimozide concentrations, which raises the risk of QT prolongation and ventricular arrhythmias. Pimozide has a narrow safety margin.
What this interaction means in plain words
Pimozide and Zileuton are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pimozide belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP3A4 (and weakly CYP1A2), reducing pimozide metabolism.
What to do
Avoid the combination and use an alternative anti-asthma therapy such as a leukotriene receptor antagonist. Monitor ECG if exposure cannot be avoided.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
- Theophylline + Zileuton Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Zileuton?
MediHelp rates the interaction as contraindicated. Pimozide and Zileuton are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Zileuton may increase pimozide concentrations, which raises the risk of QT prolongation and ventricular arrhythmias. Pimozide has a narrow safety margin.
How serious is the interaction between Pimozide and Zileuton?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative anti-asthma therapy such as a leukotriene receptor antagonist. Monitor ECG if exposure cannot be avoided.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Alosetron, Clozapine. The full list is on the Zileuton page.
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