Drug interactions
Fezolinetant + Zileuton
Severity: Contraindicated
Fezolinetant and Zileuton: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fezolinetant is cleared mainly by CYP1A2, and zileuton is a weak CYP1A2 inhibitor. Co-administration raises fezolinetant exposure and may increase the risk of adverse effects including liver injury. Labeling contraindicates fezolinetant with CYP1A2 inhibitors.
What this interaction means in plain words
Fezolinetant and Zileuton are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fezolinetant belongs to Endocrine; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, reducing fezolinetant metabolism.
What to do
Do not use together. Choose an alternative to zileuton or another vasomotor symptom therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fezolinetant and Zileuton, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zileuton
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
- Theophylline + Zileuton Major
Other interactions of Fezolinetant
- Cimetidine + Fezolinetant Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
Frequently asked questions
Can I take Fezolinetant with Zileuton?
MediHelp rates the interaction as contraindicated. Fezolinetant and Zileuton are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is cleared mainly by CYP1A2, and zileuton is a weak CYP1A2 inhibitor. Co-administration raises fezolinetant exposure and may increase the risk of adverse effects including liver injury. Labeling contraindicates fezolinetant with CYP1A2 inhibitors.
How serious is the interaction between Fezolinetant and Zileuton?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose an alternative to zileuton or another vasomotor symptom therapy.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Pimozide, Alosetron, Clozapine. The full list is on the Zileuton page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
