Drug reference
zileuton
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Respiratory (Combination(Respiratory))
Mechanism of action
Inhibitor of 5-lipoxygenase, which inhibits formation of LTB4, LTC4, LTD4, & LTE4. Inhibition of leukotriene formation reduces eosinophil and neutrophil migration, neutrophil and monocyte aggregation, capillary permeability, and smooth muscle contraction.
Common side effects
- Headache
- Abdominal
- Generalized pain
- Diarrhea
Contraindications
- Hypersensitivity Liver disease, LFT's ≥3x ULN
Known interactions (1)
- flibanserin + zileuton Moderate
Related conditions
Frequently asked questions
What drug class is zileuton?
zileuton belongs to: Respiratory.
How does zileuton work?
Inhibitor of 5-lipoxygenase, which inhibits formation of LTB4, LTC4, LTD4, & LTE4. Inhibition of leukotriene formation reduces eosinophil and neutrophil migration, neutrophil and monocyte aggregation, capillary permeability, and smooth muscle contraction.
What are the common side effects of zileuton?
Headache, Abdominal, Generalized pain, Diarrhea
Which drugs interact with zileuton?
flibanserin
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