Drug interactions
Pimozide + Zolmitriptan
Severity: Minor
Pimozide and Zolmitriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been theorised with triptans and antipsychotics, but documented cases are rare. Zolmitriptan is metabolised by CYP1A2 and MAO-A, so there is no major pharmacokinetic interaction with pimozide.
What this interaction means in plain words
Pimozide and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pimozide belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; mostly theoretical.
What to do
No routine change is needed; advise the patient to report agitation, tremor, fever or diarrhea. Evaluate promptly if symptoms of serotonin toxicity appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Pimozide with Zolmitriptan?
MediHelp rates the interaction as minor. Pimozide and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Serotonin syndrome has been theorised with triptans and antipsychotics, but documented cases are rare. Zolmitriptan is metabolised by CYP1A2 and MAO-A, so there is no major pharmacokinetic interaction with pimozide.
How serious is the interaction between Pimozide and Zolmitriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise the patient to report agitation, tremor, fever or diarrhea. Evaluate promptly if symptoms of serotonin toxicity appear.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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