Drug interactions
Pioglitazone + Ziprasidone
Severity: Minor
Pioglitazone and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics can worsen glycemic control and may offset the effect of pioglitazone. The effect with ziprasidone is typically small.
What this interaction means in plain words
Pioglitazone and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pioglitazone belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism from antipsychotic-related glucose dysregulation.
What to do
Monitor glucose and HbA1c and adjust antidiabetic therapy if control declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Pioglitazone
Frequently asked questions
Can I take Pioglitazone with Ziprasidone?
MediHelp rates the interaction as minor. Pioglitazone and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antipsychotics can worsen glycemic control and may offset the effect of pioglitazone. The effect with ziprasidone is typically small.
How serious is the interaction between Pioglitazone and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c and adjust antidiabetic therapy if control declines.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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