Drug interactions
Piroxicam + Prazosin
Severity: Minor
Piroxicam and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam may reduce the antihypertensive effect of prazosin. The effect is usually modest but can matter in patients with marginal blood pressure control.
What this interaction means in plain words
Piroxicam and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Piroxicam belongs to Musculoskeletal; Prazosin belongs to Genitourinary.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and promotion of sodium and fluid retention oppose the vasodilation from prazosin.
What to do
Check blood pressure after starting or stopping piroxicam and titrate prazosin if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Piroxicam with Prazosin?
MediHelp rates the interaction as minor. Piroxicam and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Piroxicam may reduce the antihypertensive effect of prazosin. The effect is usually modest but can matter in patients with marginal blood pressure control.
How serious is the interaction between Piroxicam and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure after starting or stopping piroxicam and titrate prazosin if needed.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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