Drug interactions
Piroxicam + Rifampin
Severity: Minor
Piroxicam and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent inducer of hepatic enzymes and may lower piroxicam concentrations, potentially reducing its effectiveness. The effect develops over one to two weeks and reverses after rifampin is stopped.
What this interaction means in plain words
Piroxicam and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induction of CYP2C9 increases piroxicam clearance.
What to do
Monitor symptom control and consider an increased piroxicam dose or alternative analgesic if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Rifampin?
MediHelp rates the interaction as minor. Piroxicam and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin is a potent inducer of hepatic enzymes and may lower piroxicam concentrations, potentially reducing its effectiveness. The effect develops over one to two weeks and reverses after rifampin is stopped.
How serious is the interaction between Piroxicam and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider an increased piroxicam dose or alternative analgesic if response is inadequate.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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