Drug interactions
Piroxicam + Rivastigmine
Severity: Moderate
Piroxicam and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of gastrointestinal ulceration and bleeding. This adds to the GI toxicity of NSAIDs such as piroxicam.
What this interaction means in plain words
Piroxicam and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Rivastigmine belongs to Central Nervous System.
Why it happens
Cholinergic stimulation of gastric acid secretion adds to NSAID-induced inhibition of protective prostaglandins.
What to do
Monitor for dyspepsia, melena and anemia, and consider a proton pump inhibitor in higher-risk patients. Avoid long-term piroxicam where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Piroxicam with Rivastigmine?
MediHelp rates the interaction as moderate. Piroxicam and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of gastrointestinal ulceration and bleeding. This adds to the GI toxicity of NSAIDs such as piroxicam.
How serious is the interaction between Piroxicam and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dyspepsia, melena and anemia, and consider a proton pump inhibitor in higher-risk patients. Avoid long-term piroxicam where possible.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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