Drug interactions
Piroxicam + Salicylates
Severity: Moderate
Piroxicam and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining piroxicam with a non-acetylated salicylate gives two prostaglandin-inhibiting drugs with overlapping toxicity. This raises the risk of gastrointestinal irritation and bleeding, renal impairment and fluid or potassium disturbances without adding meaningful benefit.
What this interaction means in plain words
Piroxicam and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition causes duplicated effects on gastric mucosa, platelet function and renal prostaglandin-dependent perfusion.
What to do
Avoid routine duplication of NSAID-type therapy; if both are used, monitor for GI bleeding, renal function and serum potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Salicylates?
MediHelp rates the interaction as moderate. Piroxicam and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining piroxicam with a non-acetylated salicylate gives two prostaglandin-inhibiting drugs with overlapping toxicity. This raises the risk of gastrointestinal irritation and bleeding, renal impairment and fluid or potassium disturbances without adding meaningful benefit.
How serious is the interaction between Piroxicam and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine duplication of NSAID-type therapy; if both are used, monitor for GI bleeding, renal function and serum potassium.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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