Drug interactions
Piroxicam + Salsalate
Severity: Moderate
Piroxicam and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID, so taking it with piroxicam duplicates NSAID effects. The combination increases the risk of gastrointestinal ulceration and bleeding, renal dysfunction and potassium retention.
What this interaction means in plain words
Piroxicam and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of prostaglandin synthesis affecting gastric protection, platelet function and renal blood flow.
What to do
Avoid concurrent use where possible and choose a single agent; if unavoidable, monitor for GI bleeding signs and check renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Piroxicam with Salsalate?
MediHelp rates the interaction as moderate. Piroxicam and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID, so taking it with piroxicam duplicates NSAID effects. The combination increases the risk of gastrointestinal ulceration and bleeding, renal dysfunction and potassium retention.
How serious is the interaction between Piroxicam and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose a single agent; if unavoidable, monitor for GI bleeding signs and check renal function and potassium.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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